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Apexbio Technology LLC Tubastatin A HCl 1310693-92-5 200mg
Supplier: Apexbio Technology LLC A8547200
Tubastatin A HCl (CAS 1310693-92-5) is a selective inhibitor of histone deacetylase 6 (HDAC6) exhibiting an IC50 of approximately 15 nM HDAC6 is involved in diverse cellular processes including transcriptional regulation cell cycle progression and neuronal development dysregulated HDAC6 activity is implicated in conditions such as Alzheimer s disease and cancer In primary cortical neuron models Tubastatin A HCl at concentrations of 5 10 M confers protection against neuronal toxicity caused by homocysteic acid In HaCaT cells its HDAC6-specific inhibition prevents arsenite-induced association of Nrf2 mRNA with ribosomes and subsequent protein translation Tubastatin A HCl also enhances cell elasticity by modulating HDAC6-mediated cytoskeletal dynamics
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