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Medchemexpress LLC Tumulosic acid | 508-24-7 | 98.7% | 486.73 | 5 MG
Supplier: Medchemexpress LLC HYN93665MG
Tumulosic acid is a triterpenoid that inhibits KLK5 protease activity. It suppresses the proteolytic processing of LL-37 in keratinocytes and decreases LL-37 production. It also shows inhibitory effects against other proteases.
- Inhibits KLK5 protease activity (IC50 = 14.84 μM)
- Suppresses proteolytic processing of LL-37 in keratinocytes (at ≤10 μM)
- Displays dose-dependent anti-KLK5 activity (IC50 = 19.3 μM)
- Decreases LL-37 production in human keratinocytes
- Shows IC50 values of 14.84 μM against KLK5
- Shows IC50 values of 10.48 μM against trypsin proteases
- Weak inhibitory effect on KLK7 and chymotrypsin C proteases (19.5% and 4.0% at 100 μM)
- For research use only
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