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Medchemexpress LLC U-0521 | 5466-89-7 | 98.7% | 25 MG
SDP

Supplier:  Medchemexpress LLC HY12194925MG

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U-0521 is a catechol-O-methyltransferase (COMT) inhibitor used for research into Parkinson's disease. It inhibits RBC COMT activity in vitro (IC50 6 x 10^-6 M) and produces dose-dependent COMT inhibition in vivo (50% at 90 mg/kg; 90% at 250 mg/kg).

  • Inhibits catechol-O-methyltransferase (COMT).
  • Shows potential for Parkinson's disease research.
  • Demonstrates in vitro activity with an IC50 of 6 x 10^-6 M against RBC COMT.
  • Produces dose-dependent in vivo COMT inhibition (50% at 90 mg/kg; 90% at 250 mg/kg in male Sprague-Dawley rats).
  • High purity (98.67%) and solid, white to off-white appearance.
  • Soluble in DMSO (100 mg/mL) with recommended in vivo formulation protocols and storage conditions.

Catalog No. 50-002-31480


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