Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
AdipoGen U-73122
Supplier: AdipoGen AGCR13698M005
Chemical. CAS 112648-68-7. Formula C29H40N2O3. MW 464.6. Gasdermin D N-terminal fragment GSDMD-N-induced pyroptosis inhibitor. Protects against GSDMD-N cytotoxicity in macrophages or against lethal infection in mice. Useful agent for inflammasome research. Potent cell permeable phospholipase C PLC , phospholipase A2 and 5-LO 5-lipoxygenase inhibitor. Affects the phospholipases by inhibiting the hydrolysis of PPI phosphatidylinositol to IP3 inositol triphosphate, which in turn leads to a drop in cytosolic Ca2. Potent inhibitor of the SERCA pump in smooth muscle. Potently inhibits Ca2-release from isolated smooth muscle cells independent of its effect on PLC. Inhibits agonist-induced platelet aggregation. Potently inhibits human polymorphonuclear neutrophil adhesion on biological surfaces and exhibits antinociceptive activity in vivo. Shown to inhibit agonist-induced down-regulation of muscarinic receptors in SK-N-SH neuroblastoma cells.
Product Content Correction
The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.
Product Title
Spot an opportunity for improvement?Share a Content Correction