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ATCC U-CH1; Chordoma; Human (Homo sapiens)
Supplier: ATCC CRL3217
U-CH1 is a mesenchymal like cell line that was isolated in 1998 from the sacrum of a 56-year-old, White male patient with chordoma. This cell line was established from a local recurrence of a sacrococcygeal after radiotherapy 4 years after initial surgery. Chordoma is a rare slow-growing tumor type, and U-CH1 is a relatively slow-growing cell line. U-CH1 has a heterogeneous morphology consisting of physaliferous cells with mucinous intercellular substance, which represent typical chordoma features. The cells overexpress the transcription factor T (Brachyury) that is the most specific marker for chordoma. This cell line was accessioned with the support of the Chordoma Foundation, a non-profit organization working to improve the lives of chordoma patients by accelerating research to develop effective treatments for the chordoma disease. This cell line was deposited by Silke Bruderlein and Peter Moller.
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