ABclonal Technology UGT1A1 Rabbit mAb

Supplier:  ABclonal Technology A22609100UL

This gene encodes a UDP-glucuronosyltransferase an enzyme of the glucuronidation pathway that transforms small lipophilic molecules such as steroids bilirubin hormones and drugs into water-soluble excretable metabolites This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases The locus includes thirteen unique alternate first exons followed by four common exons Four of the alternate first exons are considered pseudogenes Each of the remaining nine 5 exons may be spliced to the four common exons resulting in nine proteins with different N-termini and identical C-termini Each first exon encodes the substrate binding site and is regulated by its own promoter The preferred substrate of this enzyme is bilirubin although it also has moderate activity with simple phenols flavones and C18 steroids Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome

Catalog No. 50-000-05051