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Apexbio Technology LLC UK-5099 56396-35-1 50mg
Supplier: Apexbio Technology LLC A389950
UK-5099 (CAS 56396-35-1) is a potent inhibitor targeting mitochondrial pyruvate carrier (MPC) a transporter facilitating pyruvate translocation across the mitochondrial inner membrane and serving vital functions in carbohydrate lipid and amino acid metabolism UK-5099 exhibits inhibition of pyruvate uptake with a reported Ki of 49 M and fully blocks transport activity at 1 mM Additionally IC50 values of approximately 50 nM have been observed for pyruvate-dependent oxygen consumption in rat liver and cardiac mitochondria Due to its inhibitory profile UK-5099 is frequently employed in metabolic studies to investigate mitochondrial pyruvate transport mechanisms and related biological pathways
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