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Apexbio Technology LLC UNC 0631 1320288-19-4 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B11275.1
UNC 0631 (CAS 1320288-19-4) is a small-molecule inhibitor selectively targeting the protein lysine methyltransferase G9a (also known as KMT1C or EHMT2) It demonstrates potent enzymatic inhibition with an IC50 of 4 nM against G9a in SAHH-coupled assays In various cell lines UNC 0631 effectively reduces H3K9me2 levels with cellular IC50 values ranging from 18 to 72 nM indicating strong activity in epigenetic modulation Additionally it exhibits low cytotoxicity in MDA-MB-231 cells (MTT assay IC50 2 8 M) and displays improved lipophilicity properties UNC 0631 is a valuable chemical probe for investigating G9a-mediated histone methylation and associated cellular processes
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