Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Apexbio Technology LLC UNC2025 1429881-91-3 5mg
Supplier: Apexbio Technology LLC B80165
UNC2025 (CAS 1429881-91-3) is a potent orally bioavailable dual inhibitor targeting the receptor tyrosine kinases Mer and Flt3 It demonstrates low nanomolar inhibitory activity against Mer (IC50 0 8 nM) and Flt3 (IC50 0 74 nM) with selective activity over related kinases such as Axl and Tyro3 In biochemical and cellular assays UNC2025 effectively inhibits Mer phosphorylation in B-ALL and Flt3 phosphorylation in Flt3-ITD positive AML models resulting in reduced colony formation in relevant cell lines In xenograft mouse models oral administration substantially decreased Mer phosphorylation in leukemic cells UNC2025 is valuable for probing Mer and Flt3 signaling in preclinical oncological research
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?