Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Apexbio Technology LLC UNC2881 1493764-08-1 50mg
Supplier: Apexbio Technology LLC B435750
UNC2881 (CAS 1493764-08-1) is a selective inhibitor of the Mer receptor tyrosine kinase a member of the TAM (Tyro3 Axl Mer) subfamily involved in processes such as platelet aggregation and macrophage activation In biochemical assays UNC2881 demonstrates over 50% inhibition of MER and several kinases at 430 nM while in 697 B-ALL cells it inhibits Mer phosphorylation with an IC50 of 22 nM UNC2881 also suppresses ligand-dependent phosphorylation of Mer-EGFR chimeric proteins and inhibits collagen-induced platelet aggregation and ATP release in human plasma With oral bioavailability of 14% in mice and high systemic clearance UNC2881 serves as a valuable tool for investigating Mer-mediated signaling in thrombosis and related pathophysiological contexts
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?