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Apexbio Technology LLC UNC3866 1872382-47-2 25mg
Supplier: Apexbio Technology LLC A872525
UNC3866 (CAS 1872382-47-2) is a potent selective antagonist of the chromodomains in CBX4 and CBX7 exhibiting Kd values near 100 nM and 97 nM respectively Its affinity for these targets is markedly higher by 6- to 18-fold compared to other CBX and CDY chromodomains UNC3866 competitively blocks methyl-lysine recognition by Polycomb CBX and CDY family proteins as demonstrated by disruption of the CBX7-H3 interaction in AlphaScreen assays (IC50 66 nM) The compound s selectivity correlates with sequence homology and structural complementarity as shown by x-ray crystallography UNC3866 inhibits PC3 cell proliferation and serves as a chemical probe for studying chromodomain-mediated gene regulation and chromatin biology
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