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Medchemexpress LLC Upacicalcet (sodium) | 2052969-18-1 | 99.9% | 373.75 | 100 MG
Supplier: Medchemexpress LLC HY109106A10MM/1ML
Upacicalcet sodium is a non-peptide calcimimetic that acts as a CaSR agonist (EC50 = 10.8 nM). It reduces serum intact parathyroid hormone (iPTH) and serum Ca2+ levels, thereby reducing hypocalcemia and gastrointestinal complications. It improves vascular calcification and bone disorders in an Adenine-induced secondary hyperparathyroidism (SHPT) rat model, and inhibits cortical pore formation and reduces bone fibrosis in rats with chronic kidney disease (CKD). It is useful for studying SHPT.
- CaSR agonist.
- Reduces iPTH and Ca2+ levels.
- Improves vascular calcification and bone disorders.
- Inhibits cortical pore formation and reduces bone fibrosis.
- Useful for studying SHPT.
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