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Cayman Chemical UrapIdIlhydrochlorIde 250mg
SDP

Supplier:  Cayman Chemical 29004250 MG

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An α1-AR antagonist and partial 5-HT1A agonist; selectively binds to α1- over α2-ARs (IC50s = 0.74 and 42 μM, respectively) and to 5-HT1A over 5-HT1B and 5-HT2 receptors (IC50s = 0.4, 20.4, and >10 μM, respectively) in rat cortex; inhibits forskolin-induced cAMP accumulation in calf hippocampus as a functional model for 5-HT1A receptors (EC50 = 390 nM); inhibits the isoproterenol-induced positive chronotroptic response in isolated rat atria (pA2 = 6.05); lowers MAP in anesthetized cats at 1 μmol/kg, i.v.

Catalog No. 50-294-1608


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