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Cayman Chemical V-0219hydrochlorIde 10mg
Supplier: Cayman Chemical 3974010 MG
A positive allosteric modulator of GLP-1R; selective for GLP-1R over a panel of 54 other receptors, ion channels, and transporters at 10 µM; potentiates GLP-1-induced cAMP accumulation in HEK293 cells expressing human GLP-1R at 0.001-1 nM; potentiates GLP-1-induced insulin secretion in INS-1E rat insulinoma cells; improves glucose tolerance in wild-type, but not Glp1r knockout, mice at 0.1 mg/kg; enhances an exendin-4-induced reduction in food intake in rats at 0.001 mg/kg
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