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Medchemexpress LLC Vactosertib | 1352608-82-2 | 99.5% | 399.42 | 200 MG
Supplier: Medchemexpress LLC HY19928200MG
Vactosertib (EW-7197) is a potent, orally active, and ATP-competitive activin receptor-like kinase 5 (ALK5) inhibitor. It inhibits ALK2 and ALK4 at nanomolar concentrations and exhibits potent antimetastatic activity and anticancer effects. With a high purity of 99.53% and molecular weight of 399.42, this solid, off-white to yellow compound is a valuable tool for cancer research.
- Potent and orally active ALK5 inhibitor
- Inhibits ALK2 and ALK4
- Shows antimetastatic and anticancer effects
- Blocks TGFβ-induced phosphorylation of Smad2 or Smad3
- Suppresses TGFβ-induced nuclear translocation of Smad2/3
- Abrogates TGFβ1-induced tumor cell migration and invasion
- Abolishes TGFβ1-induced effects on genes related to epithelial-to-mesenchymal transition
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