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Apexbio Technology LLC VAL-083 23261-20-3 50mg

Supplier: Apexbio Technology LLC A390250
VAL-083 (CAS 23261-20-3) is a bifunctional alkylating agent with demonstrated antitumor activity It readily penetrates the blood-brain barrier and selectively targets tumor cells by inducing DNA interstrand cross-links thereby disrupting DNA replication and hindering cell proliferation Notably VAL-083 does not display cross-resistance with commonly used chemotherapeutic agents suggesting potential as a treatment option in cases of acquired resistance VAL-083 has been investigated in preclinical and clinical studies for the chemotherapy of newly diagnosed and recurrent brain tumors owing to its prolonged half-life in cerebral tissue and ability to act in tumors refractory to standard therapies
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