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Selleck Chemical LLC Vandetanib S1046-25mg
Supplier: Selleck Chemical LLC S104625MG
Vandetanib is a potent inhibitor of VEGFR2 with IC50 of 40 nM in a cell-free assay It also inhibits VEGFR3 and EGFR with IC50 of 110 nM and 500 nM respectively Not sensitive to PDGFR Flt1 Tie-2 and FGFR1 with IC50 of 1 1-3 6 M No activity against MEK CDK2 c-Kit erbB2 FAK PDK1 Akt and IGF-1R with IC50 above 10 M Vandetanib (ZD6474) increases apoptosis and induces autophagy by increasing the level of reactive oxygen species (ROS)
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