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Apexbio Technology LLC Vandetanib (ZD6474) 443913-73-3 100mg
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Supplier:  Apexbio Technology LLC A8555100

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Vandetanib (ZD6474 CAS 443913-73-3) is a small molecule inhibitor targeting both vascular endothelial growth factor receptor 2 (VEGFR-2) and epidermal growth factor receptor (EGFR) tyrosine kinases with IC50 values of 40 nM and 500 nM respectively In biochemical assays vandetanib displays stronger inhibitory activity toward VEGFR-2 compared to VEGFR-3 and VEGFR-1 In human umbilical vein endothelial cells it suppresses VEGF- and EGF-induced proliferation with IC50 values of 60 nM and 170 nM respectively Vandetanib has been shown to inhibit the growth of various cancer cell lines and to reduce tumor progression in xenograft models supporting its utility in studies of angiogenesis and targeted cancer therapies

Catalog No. 50-000-95204


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