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Enzo Life Sciences VAS-2870 (10mg). CAS: 722456-31-7
Supplier: Enzo Life Sciences BMLEI3950010
Novel inhibitor of NAD(P)H oxidase (Nox). In vascular smooth muscle cells VAS-2870 completely abolished PDGF-mediated NAD(P)H oxidase activation and ROS production (100% at 10µM). It inhibits PDGF-induced chemotaxis but not proliferation of VSMC. In mouse embryonic stem cells VAS-2870 blocked PDGF-BB-induced vasculogenesis. OxLDL-induced ROS formation in human endothelial cells was completely inhibited by VAS-2870 (100% at 5µM). VAS-2870 inhibits PMS-induced oxidative burst in HL-60 cells (IC50=2µM). Alternative name: 3-Benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo(4,5-d)pyrimidine. Purity: ≥98% (HPLC). Solubility: Soluble in DMSO (up to 10mg/ml) or DMF (up to 25mg/ml). Long Term Storage: Ambient.
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