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Apexbio Technology LLC VE-822 1232416-25-9 50mg
Supplier: Apexbio Technology LLC B138350
VE-822 (CAS 1232416-25-9) is a potent small molecule inhibitor of ATR (ATM-Rad3-related kinase) exhibiting an IC50 value of 0 019 M By specifically targeting ATR VE-822 interferes with DNA damage response mechanisms triggered by replication stress and DNA double-strand breaks processes frequently activated following chemotherapy or radiotherapy (XRT) Preclinical studies demonstrate that VE-822 disrupts cell cycle checkpoint signaling and homologous recombination enhancing persistent DNA damage in cancer cells In pancreatic tumor xenograft models VE-822 selectively sensitizes tumors rather than normal tissues to radiation and gemcitabine treatments highlighting its potential utility in oncology research aimed at exploiting DNA repair pathway vulnerabilities
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