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Medchemexpress LLC Vecabrutinib | 1510829-06-7 | 529.92 | 25 MG
Supplier: Medchemexpress LLC 25MGHY109078
Vecabrutinib (SNS-062) is a potent, noncovalent BTK and ITK inhibitor. It demonstrates high potency with Kd values of 0.3 nM for BTK and 2.2 nM for ITK, and an IC50 of 24 nM for ITK. This compound retains activity against mutated BTK variants and is well-tolerated in vivo.
- Potent noncovalent BTK and ITK inhibitor
- Active against mutated BTK variant
- Six times more potent than PCI-32765 against C481S BTK
- Good oral bioavailability in rat and dog
- Decreases viability of primary CLL cells
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