ABclonal Technology VEGFA Mouse mAb

Supplier:  ABclonal Technology A17877100UL

This gene encodes a heparin-binding protein from the PDGF-VEGF growth factor family existing as a disulfide-linked homodimer It induces vascular endothelial cell proliferation and migration playing a key role in both physiological and pathological angiogenesis Disruption in mice leads to abnormal blood vessel formation This gene is upregulated in many tumors with expression linked to tumor stage and progression Elevated levels are found in patients with POEMS syndrome Variants are associated with microvascular complications of diabetes and atherosclerosis Alternative splicing and translation initiation result in various isoforms including a C-terminally extended antiangiogenic isoform VEGF levels increase during SARS-CoV-2 infection promoting inflammation by recruiting inflammatory cells and elevating angiopoietin II forming a vicious cycle with cytokine release

Catalog No. 50-000-07981