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Medchemexpress LLC VH-298 | 2097381-85-4 | MFCD30742947 | >98.0% | 523.6 g/mol | C27H33N5O4S | 100 MG
SDP

Supplier:  Medchemexpress LLC HY100947100MG

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VH-298 is a cell-permeant, small-molecule inhibitor of the von Hippel-Lindau (VHL) : hypoxia-inducible factor alpha (HIF-α) protein-protein interaction. It stabilizes HIF-α in cells by blocking VHL recognition and is used in biochemical and cellular research, including as an E3 ligase ligand in targeted protein degradation studies.

  • Inhibits the VHL:HIF-α protein-protein interaction (Kd ≈ 80-90 nM).
  • Stabilizes HIF-α in cells for hypoxia-response and signaling studies.
  • Useful as an E3 ligase ligand in PROTAC design and targeted degradation research.
  • Cell-permeant small molecule suitable for cellular assays.
  • Reported purity ≥98% (HPLC); molecular weight 523.6 g/mol.

Catalog No. 50-002-11735


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