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Medchemexpress LLC Vimentin-IN-1 | 2319587-80-7 | C19H18Cl2N4O | 1 ML
Supplier: Medchemexpress LLC HY15142410MM/1ML
Vimentin-IN-1 is a derivative of FiVe1, functioning as an orally active and selective anticancer agent. It targets and binds to the type III intermediate filament protein vimentin (VIM), leading to hyperphosphorylation of Ser56. This action results in the selective disruption of mitosis and multinucleation in transformed VIM-expressing mesenchymal cancer cells. Compared to FiVe1, Vimentin-IN-1 exhibits improved oral bioavailability and pharmacokinetic profiles.
- Orally active and selective anticancer agent
- Targets type III intermediate filament protein vimentin (VIM)
- Induces hyperphosphorylation of Ser56
- Leads to selective disruption of mitosis and multinucleation in cancer cells
- Shows improved oral bioavailability and pharmacokinetic profiles
- Inhibits HT-1080 fibrosarcoma with an IC50 value of 44 nM
- Induces phosphorylation of VIM at Ser56
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