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Apexbio Technology LLC VKGILS-NH2 942413-05-0 5mg
Supplier: Apexbio Technology LLC A86715
VKGILS-NH2 (CAS 942413-05-0) is a synthetic peptide that serves as the reverse-sequence control for the protease-activated receptor 2 (PAR2) agonist SLIGKV-NH2 PAR2 a G protein-coupled receptor expressed in airway and gastrointestinal tissues is implicated in inflammatory responses and vascular regulation In vitro studies have used VKGILS-NH2 to differentiate nonspecific effects from PAR2 activation showing that in contrast to the agonist VKGILS-NH2 does not enhance mucin secretion in bronchial epithelial cells In vivo VKGILS-NH2 functions as a negative control lacking the vasodilatory or contractile responses observed with PAR2 agonists supporting its use in mechanistic studies of PAR2 signaling
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