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Medchemexpress LLC Voacangine | 510-22-5 | 1 MG
Supplier: Medchemexpress LLC HYN75361MG
Voacangine is an antagonist for TRPV1 and TRPM8, and an agonist for TRPA1 (EC50=8 μM). It competitively blocks capsaicin binding to TRPV1 (IC50=50 μM) and inhibits menthol binding to TRPM8 (IC50=9 μM). It is isolated from the root bark of Voacanga africana.
- Antagonist for TRPV1 and TRPM8.
- Agonist for TRPA1 (EC50=8 μM).
- Competitively blocks capsaicin binding to TRPV1 (IC50=50 μM).
- Competitively inhibits the binding of menthol to TRPM8 (IC50=9 μM).
- Shows noncompetitive inhibition against icilin (IC50=7 μM).
- Selectively abrogates chemical agonist-induced TRPM8 activation.
- Does not affect cold-induced TRPM8 activation.
- Alkaloid isolated from the root bark of Voacanga africana.
- Purity: 98.78%.
- Appearance: Solid, white to off-white.
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