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Medchemexpress LLC Voreloxin Hydrochloride | 175519-16-1 | 99.6% | 437.90 | 100 MG

Supplier: Medchemexpress LLC HY16518100MG
Voreloxin Hydrochloride is a first-in-class topoisomerase II inhibitor that intercalates DNA and induces site-selective DNA DSB, G2 arrest, and apoptosis.
- A first-in-class topoisomerase II poison and inhibitor that intercalates DNA and induces site-selective DNA DSB, G2 arrest, and apoptosis.
- Inhibits topoisomerase II activity and induces site-selective DNA DSB.
- Induces G2 arrest partially through topoisomerase II.
- Cytotoxic activity requires DNA intercalation.
- Demonstrates potent cytotoxic activity in AML cell lines.
- Causes accumulation of cells in the S and G2 phases of the cell cycle and acts on topoisomerase II.
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