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Medchemexpress LLC Voreloxin Hydrochloride | 175519-16-1 | 99.6% | 437.90 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY16518100MG

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Voreloxin Hydrochloride is a first-in-class topoisomerase II inhibitor that intercalates DNA and induces site-selective DNA DSB, G2 arrest, and apoptosis.

  • A first-in-class topoisomerase II poison and inhibitor that intercalates DNA and induces site-selective DNA DSB, G2 arrest, and apoptosis.
  • Inhibits topoisomerase II activity and induces site-selective DNA DSB.
  • Induces G2 arrest partially through topoisomerase II.
  • Cytotoxic activity requires DNA intercalation.
  • Demonstrates potent cytotoxic activity in AML cell lines.
  • Causes accumulation of cells in the S and G2 phases of the cell cycle and acts on topoisomerase II.

Catalog No. 50-003-91804


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