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Medchemexpress LLC VU0469650 | 1443748-47-7 | 98.7% | 364.48 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY11019110MG

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VU0469650 is a potent, selective, and brain-penetrant negative allosteric modulator of the mGlu1 receptor, with an IC50 of 99 nM. It is intended for research use only.

  • Potent, selective, and brain-penetrant negative allosteric modulator of mGlu1 receptor.
  • IC50 of 99 nM for mGluR 1.
  • Exhibits moderate to high clearance, a moderate volume of distribution, and a half-life of approximately 1 hour in male Sprague-Dawley rats (0.2 mg/kg, IV).
  • Shows excellent selectivity profile and good exposure in both plasma and brain samples in male Sprague-Dawley rats (10 mg/kg, IP).
  • Suitable for research applications as a tool compound.
  • Good CNS exposure in rats.

Catalog No. 50-003-44238


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