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Medchemexpress LLC WAY-600 | 1062159-35-6 | MFCD22419019 | C28H30N8O | 50 MG
Supplier: Medchemexpress LLC HY1527250MG
WAY-600 is a potent, ATP-competitive, and selective mTOR inhibitor with an IC50 of 9 nM for the recombinant mTOR enzyme. It effectively blocks mTOR complex 1/2 (mTORC1/2) assembly and activation, demonstrating significant anti-cancer activity in vitro against HepG2 and Huh-7 cells and in vivo by inhibiting HepG2 tumor growth in nude mice.
- Potent, ATP-competitive, and selective mTOR inhibitor
- Blocks mTOR complex 1/2 assembly and activation
- Inhibits HepG2 and Huh-7 cell viability
- Decreases HepG2 cell colonies
- Increases caspase-3 and caspase-9 activity in HepG2 cells
- Inhibits HepG2 tumor growth in nude mice
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