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Medchemexpress LLC WBC100 | 2095780-08-6 | 95.0% | C25H33NO7 | 1 ML
SDP

Supplier:  Medchemexpress LLC HY14589810MM/1ML

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WBC100 (14-D-Valine-TPL) is a potent, selective, and orally active c-Myc molecule glue degrader. It targets the ubiquitin E3 ligase CHIP-mediated 26S proteasome pathway and is utilized in research for c-Myc overexpressing tumors. This compound exhibits significant biological activity both in vitro and in vivo.

  • Acts as a potent, selective, and orally active c-Myc molecule glue degrader.
  • Targets the ubiquitin E3 ligase CHIP-mediated 26S proteasome pathway.
  • Selectively kills c-Myc overexpressing cancer cells with nanomolar IC50 values.
  • Shows higher IC50 values for c-Myc-low normal human cell lines.
  • Decreases c-Myc protein levels in cancer cells in a dose-dependent manner.
  • Exhibits dose-dependent antitumor activity in vivo.
  • Can eradicate MOLM-13-luciferase cells in vivo at effective doses.
  • Significantly inhibits tumor growth and prolongs survival in leukemia models.

Catalog No. 50-003-53851


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