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Apexbio Technology LLC Windorphen 19881-70-0 5mg
Supplier: Apexbio Technology LLC B59775
Windorphen (CAS 19881-70-0) is a small molecule inhibitor that selectively suppresses Wnt/ -catenin signaling primarily interfering with Wnt-mediated processes involved in ventral embryonic development In STF293 reporter cells Windorphen inhibits Wnt3a-induced TOPFLASH luciferase activity in a dose-dependent manner (IC50 1 5 mM) In human colon adenocarcinoma SW480 cells with constitutively active Wnt signaling treatment with Windorphen for 72 hours induces significant apoptosis In zebrafish embryos Windorphen selectively inhibits ventral and lateral Wnt activity and can rescue forebrain/eye defects in models with dysregulated Wnt signaling This compound is valuable for studying Wnt pathway modulation in developmental biology and cancer research
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