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AdipoGen Withaferin A
SDP

Supplier:  AdipoGen AGCN20490M005

Encompass_Preferred

Chemical. CAS 5119-48-2. Formula C28H38O6. MW 470.6. Isolated from Withania somnifera. Multifunctional anticancer compound. Amplifies the cellular antioxidant and/or detoxification system, suppresses inflammatory pathways, selectively inhibits tumor cell proliferation and induces apoptosis, suppresses tumor angiogenesis, blocks epithelial-to-mesenchymal transition EMT, tumor invasion and metastasis, alters tumor cell metabolism, induces immunomodulation and downregulates cancer stem cells targets. Sensitizes resistant cancer cells to existing chemotherapeutic agents. Antioxidant. Induces cytoprotective enzymes Nrf2-dependent as well, including SOD, HO-1 heme oxygenase-1, catalase, glutathione peroxidise, glutathione s-transferase and NQO1. Anti-inflammatory agent. Inhibits COX-2 and iNOS expression at protein and mRNA level and PGE2 production. Prevents NF-kappaB activation by inhibiting activation of IKKbeta.

Catalog No. 50-256-2509


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