Medchemexpress LLC Wm382 | 2606990-92-3 | C29H36N4O4 | 1 MG

Supplier:  Medchemexpress LLC HY1515611MG

WM382 is an orally active and potent dual plasmepsin IX/X (PMIX/X) inhibitor with IC50 values of 1.4 nM and 0.03 nM, respectively. It demonstrates robust in vivo efficacy at multiple stages of the malaria parasite life cycle and possesses an excellent resistance profile.

• Orally active and potent dual plasmepsin IX/X inhibitor
• Robust in vivo efficacy at multiple stages of malaria parasite life cycle
• Excellent resistance profile
• Shows moderate cytotoxicity against HepG2 cells (IC50=24.8 μM)
• Inhibits *Plasmodium falciparum* and *P. vivax* with an IC50 value of 0.6 nM (*P. falciparum*)
• Selectively binds PMV and PMX
• Prolongs time to patent blood infection in *P. berghei*-infected HepG2 in vitro cultures
• Clears mouse models of *P. berghei* and *P. falciparum* parasites
• Efficacious against *P. falciparum* asexual infection in humanized mice
• Prevents transmission to mosquitoes

Catalog No. 50-003-72391