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Medchemexpress LLC WM382 | 2606990-92-3 | C29H36N4O4 | 5 MG
Supplier: Medchemexpress LLC HY1515615MG
WM382 is an orally active and potent dual plasmepsin IX/X (PMIX/X) inhibitor. It exhibits robust in vivo efficacy at multiple stages of the malaria parasite life cycle and possesses an excellent resistance profile. It shows moderate cytotoxicity against HepG2 cells and inhibits Plasmodium falciparum and P. vivax. WM382 can clear mouse models of P. berghei and P. falciparum parasites, and is efficacious against P. falciparum asexual infection in humanized mice, preventing transmission to mosquitoes.
- Potent dual plasmepsin IX/X (PMIX/X) inhibitor
- Robust in vivo efficacy at multiple stages of the malaria parasite life cycle
- Excellent resistance profile
- Moderate cytotoxicity against HepG2 cells
- Inhibits Plasmodium falciparum and P. vivax
- Efficacious against Plasmodium falciparum asexual infection in humanized mice
- Prevents transmission to mosquitoes
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