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Apexbio Technology LLC WYE-125132 (WYE-132) 1144068-46-1 200mg
Supplier: Apexbio Technology LLC B1642200
WYE-125132 (WYE-132) [CAS 1144068-46-1] is a potent ATP-competitive inhibitor of mammalian target of rapamycin (mTOR) displaying high selectivity over PI3K isoforms It effectively targets both mTORC1 and mTORC2 complexes as demonstrated by inhibition of S6K (T389) and AKT (S473) phosphorylation in immunocomplex assays with an IC50 of 0 19 0 07 nM WYE-125132 suppresses phospho-S6K and phospho-AKT in IGF-I stimulated or mutant cell lines at low nanomolar EC50 values and inhibits proliferation across multiple cancer cell models The compound is widely utilized in research to study mTOR signaling and its role in cellular proliferation and protein synthesis
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