Apexbio Technology LLC WYE-687 1062161-90-3 20mg

Supplier:  Apexbio Technology LLC B163820

WYE-687 (CAS 1062161-90-3) is an ATP-competitive inhibitor targeting the mammalian target of rapamycin (mTOR) kinase exhibiting potent inhibition of both mTORC1 and mTORC2 isoforms with an IC50 of 7 nM In immunocomplex kinase assays using His6-AKT and His6-S6K as substrates WYE-687 effectively blocks mTOR-mediated phosphorylation in a dose-dependent manner It demonstrates high selectivity for mTOR over PI3K and PI3K and a range of other kinases In tumor cell lines such as MDA361 and HCT116 WYE-687 induces G1 phase cell cycle arrest and suppresses cell proliferation Additionally it reduces HIF-1 expression implicating potential effects on angiogenic signaling

Catalog No. 50-000-90623