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Apexbio Technology LLC WZ3146 1214265-56-1 50mg
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Supplier:  Apexbio Technology LLC A888150

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WZ3146 (CAS 1214265-56-1) is an irreversible inhibitor targeting mutated epidermal growth factor receptor (EGFR) specifically the L858R and E746 A750del variants with an IC50 of 2 nM for both mutants In non-small cell lung cancer (NSCLC) cell lines WZ3146 suppresses EGFR phosphorylation including in those harboring the T790M resistance mutation Mass spectrometry analyses indicate covalent bond formation between WZ3146 and the EGFR kinase domain predominantly at Cys797 WZ3146 serves as a valuable tool for investigating mutant-selective EGFR inhibition and resistance mechanisms in NSCLC research models

Catalog No. 50-000-95915


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