Cayman Chemical XalIprodenhydrochlorIde 10mg

Supplier:  Cayman Chemical 3146810 MG

A 5-HT1A agonist (IC50 = 4.3 nM in a radioligand binding assay); selective for 5-HT1A over 5-HT2 and α1-adrenergic receptors (IC50s = 697 and 630 nM, respectively), as well as a panel of 13 additional neurotransmitter receptors and ion channels (IC50s = ≥10 µM for all) but also binds σ receptors (IC50 = 73 nM); increases NGF-induced neurite outgrowth and α-actinin levels in PC12 cells at 250 nM; decreases hippocampal neuronal damage and reduces impairments in sensorimotor function in rat models of transient global ischemia induced by 4-VO and sciatic nerve crush injury, respectively, at 10 mg/kg per day; inhibits CNS mononuclear cell infiltration and increases in cerebrospinal fluid IgG levels in a rat model of EAE induced by myelin basic protein at 10 mg/kg per day

Catalog No. 50-299-2155