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Apexbio Technology LLC XAV-939 284028-89-3 100mg
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Supplier:  Apexbio Technology LLC A1877100

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XAV-939 (CAS 284028-89-3) is a selective small-molecule inhibitor targeting tankyrase 1 and 2 with reported IC values of approximately 11 nM and 4 nM respectively Initially identified as an inhibitor of the Wnt/ -catenin signaling pathway XAV-939 inhibits tankyrase catalytic domains resulting in stabilization of Axin protein and subsequent downregulation of -catenin activity In cellular assays using HEK293 and SW480 cells XAV-939 treatment reduced Wnt-induced -catenin accumulation and increased its phosphorylation This compound serves as a valuable research tool for investigating Wnt-related cellular processes and potential therapeutic interventions

Catalog No. 50-000-62782


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