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Medchemexpress LLC XAV-939 | 284028-89-3 | MFCD08272370 | C14H11F3N2OS | 1 G
Supplier: Medchemexpress LLC HY151471G
XAV-939 is a potent and selective Tankyrase (TNKS) inhibitor that targets TNKS1 and TNKS2 with IC50 values of 5 nM and 2 nM, respectively. It functions by inducing β-catenin degradation through the stabilization of Axin. This compound is valuable for research into conditions associated with activated Wnt signaling, including various cancers, fibrotic diseases, and disorders characterized by low bone formation. It also enhances the osteoblastic differentiation of hMSCs.
- Potent and selective Tankyrase (TNKS) inhibitor
- Induces β-catenin degradation
- Stabilizes Axin
- Enhances osteoblastic differentiation of hMSCs
- Useful for research of Wnt signaling-related conditions
- Relevant for studies on cancer, fibrotic diseases, and low bone formation conditions
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