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Medchemexpress LLC XE991 dihydrochloride | 122955-13-9 | 99.6% | 449.37 | 25 MG
SDP

Supplier:  Medchemexpress LLC 25MGHY108577

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XE991 dihydrochloride is a Kv7 (KCNQ) channels blocker that potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channels, and M-current. It demonstrates good in vivo potency and duration of action.

  • Inhibits Kv7.1 channel with an IC50 of 0.75 μM
  • Inhibits Kv7.2 channel with an IC50 of 0.71 μM
  • Inhibits Kv7.2 + Kv7.3 channel with an IC50 of 0.6 μM
  • Inhibits M-current with an IC50 of 0.98 μM
  • Shows an EC50 of 490 nM for enhancing [3H]ACh release from rat brain slices

Catalog No. 50-003-47217


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