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Medchemexpress LLC Xevinapant | 1071992-99-8 | 99.9% | 561.71 | 50 MG
Supplier: Medchemexpress LLC 50MGHY15454
Xevinapant is a potent and orally bioavailable Smac mimetic and an antagonist of IAPs, binding to XIAP, cIAP1, and cIAP2 proteins. It has been shown to inhibit tumor growth and induce apoptosis in various cancer cell lines.
- Potent and orally bioavailable Smac mimetic
- Antagonist of IAPs, binding to XIAP, cIAP1, and cIAP2 proteins
- Induces rapid cellular cIAP1 degradation and pulls down cellular XIAP protein
- Effectively inhibits various human cancer cell lines
- Shows low toxicity against normal-like human breast epithelial cells
- Induces apoptosis by activating caspase-3 and cleaving PARP
- Effective in inhibiting tumor growth in xenograft models with minimal toxicity
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