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Apexbio Technology LLC XL388 1251156-08-7 50mg
Supplier: Apexbio Technology LLC A394050
XL388 (CAS 1251156-08-7) is a selective orally bioavailable inhibitor of mammalian target of rapamycin (mTOR) It exhibits potent activity against both mTOR complexes displaying an IC50 of 9 9 nM for mTOR kinase inhibition In cell-based assays XL388 blocks mTORC1-dependent phosphorylation of p70S6K (IC50 94 nM) and mTORC2-dependent phosphorylation of AKT (IC50 350 nM) in MCF-7 cells leading to reduced proliferation of hematological tumor cell lines and enhanced chemosensitivity In vivo once-daily oral administration of XL388 significantly suppresses tumor growth in several xenograft models with pronounced inhibition observed in MCF-7 xenografts It is valuable for investigating mTOR pathway modulation in cancer research
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