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TARGETMOL CHEMICALS INC XL888 5MG

Supplier: TARGETMOL CHEMICALS INC T62485MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. XL888 is an ATP-competitive inhibitor of Hsp90 ( IC50 24 nM). Heat shock protein 90 (Hsp90) is a chaperone that maintains the functionality of client proteins involved in cell proliferation cell cycling and apoptosis. Through this action specific client proteins are degraded resulting in cell cycle arrest or apoptosis. XL888 is orally bioavailable and shows efficacy in tumor regression in gastric carcinoma and melanoma xenografts in mice. purity: 98%
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