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Apexbio Technology LLC YC 1 170632-47-0 200mg
Supplier: Apexbio Technology LLC B7641200
YC-1 (CAS 170632-47-0) is a small molecule originally identified as an inhibitor of hypoxia-inducible factor-1 (HIF-1 ) a transcription factor that regulates genes involved in angiogenesis cell survival and tumor progression under hypoxic conditions YC-1 suppresses the transcriptional activity of HIF-1 with an IC50 of 1 2 M and inhibits HIF-1 expression at the post-transcriptional level in hypoxic hepatocellular carcinoma cell models In vivo YC-1 reduces tumor size and vascularization accompanied by decreased expression of HIF-1 and HIF-1-regulated genes YC-1 serves as a tool for investigating HIF-1 signaling pathways and their roles in cancer biology and hypoxia-associated diseases
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