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Selleck Chemical LLC YD23 E1985-1G
Supplier: Selleck Chemical LLC E19851G
YD23 is a PROTAC which induces the degradation of SMARCA2 It reduces chromatin accessibility in SMARCA4-deficient cells affecting gene enhancers related to cell cycle and growth regulation which leads to the downregulation of several cell cycle genes It also selectively inhibits the growth of SMARCA4 mutant lung cancer cells in vitro
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