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Medchemexpress LLC YM-1 | 409086-68-6 | 98.49% | 417.98 | 100 MG
Supplier: Medchemexpress LLC HY18399100MG
YM-1 is a stable MKT-077 analog and an orally active Hsp70 inhibitor. It induces cell death in HeLa cells and up-regulates the levels of p53 and p21 proteins. For research use only, not for sale to patients.
- Stable MKT-077 analog
- Orally active Hsp70 inhibitor
- Induces cell death of HeLa cells
- Up-regulates p53 and p21 proteins
- Promotes Hsp70-dependent steps in nNOS maturation
- Partially blocks formation of the ATP-bound form of Hsp70
- Activates binding of Hsp70 to its unfolded substrate
- Converts Hsp70 to its tight-affinity conformation with an IC50 of 8.2 μM
- Promotes nNOS ubiquitination
- Weakens dihydrotestosterone (DHT)-dependent eye degeneration phenotype and rescues DHT-dependent pupal toxicity of polyQ AR in Drosophila
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