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Medchemexpress LLC (Z)-3-((1H-indol-2-yl)methylene)-4-((4-hydroxypiperidin-4-yl)ethynyl)indolin-2-one | 00-00-0 | 98.2% | C24H21N3O2 | 10MG
SDP

Supplier:  Medchemexpress LLC HY13943910MG

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SBI-581 is an orally active, selective serine-threonine kinase TAO3 inhibitor with a reported IC50 of about 42 nM. It affects TKS5α trafficking, inhibits invadopodia formation, and has shown antitumor activity with reasonable pharmacokinetics in mouse studies; the molecule also contains an alkyne group suitable for click chemistry applications.

  • Selective TAO3 inhibition with potent activity (~42 nM).
  • Promotes TKS5α accumulation in RAB11-positive vesicles.
  • Inhibits invadopodia formation, reducing invasive behavior.
  • Demonstrated in vivo activity and reasonable pharmacokinetics in mice.
  • Contains an alkyne group compatible with copper-catalyzed click chemistry.

Catalog No. 50-002-60814


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