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Medchemexpress LLC Z-3578 | 473687-20-6 | 98.72% | 467.37 | 25 MG
Supplier: Medchemexpress LLC 25MGHY172458
Z-3578 is an orally active small-molecule antagonist of MrgX2 with potent antipseudoallergic activity. It effectively inhibits mast cell degranulation and can be used for the study of pseudoallergic reactions.
- Inhibits mast cell degranulation induced by substance P and C48/80
- Suppresses the release of β-hexosaminidase
- Significantly reduces the release of histamine and TNF-α
- Decreases intracellular calcium flux
- Alleviates paw swelling and dye extravasation in a mouse pseudoallergy model
- Reduces serum histamine levels in a mouse pseudoallergy model
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