Apexbio Technology LLC Z-FY-CHO 167498-29-5 1mg

Supplier:  Apexbio Technology LLC A90781

Z-FY-CHO (CAS 167498-29-5) is a potent and selective inhibitor of cathepsin L exhibiting an IC50 of 0 85 nM It demonstrates significantly higher selectivity for cathepsin L over cathepsin B (IC50 85 1 nM) and cathepsin K (IC50 184 nM) In cellular assays Z-FY-CHO shows cytotoxic activity against Trypanosoma brucei (ED50 45 nM) with markedly reduced effects on human HL-60 cells (ED50 21 500 nM) The compound completely inhibits osteoclast-mediated bone resorption at 1 g/ml In murine osteoporosis models Z-FY-CHO produces dose-dependent inhibition of bone loss at 2 5 10 mg/kg This inhibitor serves as a valuable tool for investigating cathepsin L function in proteolysis parasitic infection and bone resorption studies

Catalog No. 50-000-93972